best items to unlock isaac: repentance

10 Magneto. Displays a random cryptic message on the screen similar to the fortune machine ones. Based on the Steam Workshop mod created by Amethyst, UNLOCK: Unlock this item by using 5 Gulp! If it touches an enemy it breaks and leave a pool on the floor which freezes enemies and deals 8 damage per tick, * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, The chance for this effect to activate depends on your Luck stat. The longer the button is held the faster Gurdy will fling itself across the screen, Deals a fixed amount of damage depending on charge level, at lowest being ~5 and at max being ~20, Lil Gurdy bounces off of enemies and obstacles, A beggar head which floats around the room and picks up any nearby coins. The Lost starts with this item after donating 879 coins to the Greed Donation Machine. Abel, UNLOCK: Unlock this trinket by defeating Isaac, ?? * boss room pool, boss room item, mr. squeezy, mr squeezy, cobaltstreak, white, brown, red, bow, * boss room pool, boss room item, purple, carton, grape drank, When picked up, spawns 1 red heart, 1 key, 1 bomb, 1 coin, 1 card/rune, 1 pill and 1 trinket, * dungeon room, blood challenge room, arena pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item, brown, orange, cardboard, Doubles the yield of hearts, coins, bombs and keys that spawn from non-red chests, Item Pool: Shop, Challenge Room, Key Beggar, Mom's Chest, * key master pool, key beggar pool, key judgement pool, , dungeon room, blood challenge room, arena pool, shop room pool, shop item pool, golden, horns, moms key, mom key, Tears have a random chance to charm enemies, Charmed enemies will prioritize attacking other enemies in the room, otherwise they will still attack Isaac, The chance to charm enemies is affected by your luck stat and at +27 Luck it will activate every time, * dungeon room, blood challenge room, arena pool, item room, treasure room, item room pool, Broken hearts permanently subtract from your total possible health containers, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Magdalene, Isaac turns to stone and can't move for 10 seconds, but your tear rate goes up significantly for the duration, UNLOCK: Unlock this card by defeating challenge #42 (Hot Potato), UNLOCK: Unlock this card by defeating challenge #43 (Cantripped), "May you see the value of all things in life", When used, all items and pickups in the current room are turned into money. After like 800h, it got to the point where i rarely lost any run. Demo man unlocks a card that can instantly kill any enemy, including end bosses. After reaching level 4 (and at a much lower chance before level 4), Bumbo will also continue to collect coins and drop random pickups, similar to the Bum Friend item, but can also drop pedestal items very rarely. I included Stairway in this list because this item is their strongest (and relatively easiest) unlock - it wins runs on its own, since the shop provides you with additional Angel items, Angel statues, and beggars to bomb even more Angel/Devil Rooms. I would understand if they would tune down normal mode tho, but leaving hard mode as it is presents a nice option for people who want a challenge. With respect to how to find these rooms, the initial chance of a Planetarium appearing is jus When the effect wears off, Isaac quickly runs between each marked enemy, dealing high damage to each one rapidly (roughly x2.5 your tear damage), The damage caused by this effect scales up with every target it hits in a row, UNLOCK: Unlock this item by defeating Delirium as Tainted Judas, *, budas, jubas, sword, blood, omae wa mou shindeiru, When used, Abyss consumes all pedestal items in the current room and converts them into Red attack flies, Red attack flies will charge across the room in the same direction Isaac is shooting, dealing contact damage to enemies equal to Isaac's tear damage, The flies don't block enemy shots, but this also means they never die and stay with Isaac forever, UNLOCK: Unlock this item by defeating Delirium as Tainted Apollyon, Staples one of Isaac's eyes shut, meaning he only shoots tears from one eye. Item Pool: Item Room, Secret Room, Crane Game, Taking damage for the first time in a room spawns a familiar which targets an enemy and jumps on them, releasing a rock wave outwards, For the remainder of the room the familiar then continues to attack enemies similar to the Dead Bird item dealing 3 contact damage per tick. in a small boss room), UNLOCK: Unlock this item by defeating Greedier Mode with Lilith, Gives you a 100% chance to find an Angel Room on every valid floor after defeating the boss, Doesn't spawn an angel room on any floor where it is normally not possible to find one (e.g. Here's the information about best items to unlock isaac People use search engines every day, but most people don't know some tricks that can help them get better search results, for example: when searching for "dog", "dog -black"(without quotation marks) can help you exclude search results that contain "black". Also summons a blue crosshair which can be moved around freely. At the full 12 charges Isaac does a massive shout, dealing 356 damage to all enemies on the screen, Larynx gains 1 charge every time you take damage (also charges as normal), UNLOCK: Unlock this item by defeating The Beast as Tainted Samson, Recharge time: 12 rooms (Can be used with partial charges), This item gives you a familiar version of The Lost character which dies instantly upon hit, If the familiar survives an entire floor you get one of: 3 soul hearts, 2 eternal hearts or a random item/angel room item, Regenerates at the start of each floor if dead, UNLOCK: Unlock this item by defeating Mother in the Corpse II as The Lost, Bombs now spawn a puddle of red creep upon explosion, dealing 2 damage per tick to enemies touching it, While at 0 bombs, you can also place further bombs now at the cost of 1/2 of a heart (kills The Lost if used like this). The Binding of Isaac: Repentance . The locust fly will do different things for each harbinger - e.g. yellow book how to, * boss room pool, boss room item, bone, red, brown, Gives Isaac a random tarot card when picked up, * boss room pool, boss room item, eight, grey, gray, Drops 4 random pills on the floor around Isaac, Item Pool: Shop, Boss Room, Challenge Room, Beggar, Demon Beggar, Mom's Chest, * dungeon room, blood challenge room, arena pool, demon beggar pool, demon judgement pool, devil beggar pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item, shop room pool, shop item pool, bag, pouch, moms coin purse, mom coin purse. The Binding of Isaac: Repentance is a massive expansion to The Binding of Isaac: Afterbirth+ that makes the game feel like a completely new roguelike with its sheer amount of features. Function: Every item pedestal cycles through 5 different options really fast, Unlock Condition: Defeat the Beast as Tainted Isaac. ), *, money, silver, grey, gray, steam, smoke, cent, Everytime you pick up a coin, you have a 25% chance to spawn a key, *, white, grey, gray, coin, cent, money, cash, When picking up a coin, you have a chance to automatically gain one more coin, UNLOCK: Unlock this item by playing the shell game in the arcade 100 times, *, yellow, golden, coin, cent, money, cash, sparkle, When you enter a boss room, immediately remove 15% health from the boss and restore 1 red heart, This trinket cannot be dropped by holding the drop key or picking up other trinkets. See the dedicated Devil room page for more details, First half of the key required to enter the door to the Mega Satan boss, Drops from one of the angels which appear by bombing the statue in an angel room, * angel room, angels, broken, yellow, gold, circle, Second half of the key required to enter the door to the Mega Satan boss, Randomly increases 4 of your stats, and decreases 2 of them, Possible stat changes are fixed values: 1 health, 1 damage, 0.2 speed, 0.5 range, 0.5 tears, 0.2 shot speed, 1 luck, UNLOCK: Unlock this item by beating Mom's Heart 7 times, * demon beggar pool, demon judgement pool, devil beggar pool, boss room pool, boss room item, item room, treasure room, item room pool, yellow syringe, needle, injection, Doubles pickups and chests from clearing a room, Also gives a 30% chance for room clear rewards to not spawn, Doesn't affect coins spawned in Greed Mode, * curse room pool, demon beggar pool, demon judgement pool, devil beggar pool, devil pool, This effect stacks with multiple shades, scaling the contact damage each time, UNLOCK: Unlock this item by defeating Delirium in The Void floor with Judas, Isaac gains a cloud familiar that follows him and leaves a trail of tears on the floor which damages enemies for 2 damage per tick, Enemies touching the cloud have a chance to activate the Crack the Sky effect, which spawns a light beam that deals damage equal to your tear damage + 20, Gives Isaac a small Hush familiar that bounces diagonally around the room dealing 2 contact damage per tick, While you're firing tears Hushy will stop moving, which allows you to keep it in one place, Hushy will block enemy tears and projectiles, UNLOCK: Unlock this item by beating Hush with Apollyon, Gives Isaac a small Monstro familar, who's tears can be charged and released in a shotgun style effect, much like Monstro's main attack, Lil Monstro's tears each deal base damage (3.5) and don't scale with damage upgrades, *, head, cleft, lip, palate, hairlip, tooth, A baby familiar that follows you and causes other familiars to follow it. The spear occasionally inflicts fear on enemies it damages. - Destroys all poops in the room and spawns a blue attack spider on every destroyed poop, Infested? While in this form you can walk over enemies to mark them for death. After reflecting a certain number of projectiles, Psy Fly enters a brief cooldown period. Midnight Snack = +1 flat damage, +1 luck. It can take you to rooms that require bombs/keys, e.g. * item room, treasure room, item room pool, money is power, dollar, red, grey, gray, Tears now have a random chance to freeze enemies in place, The chance to freeze enemies is affected by your luck stat, Chance to activate increases with luck, up to around 50% chance at +20 luck, UNLOCK: Unlock this item by collecting 3 'Mom' items in one playthrough, * item room, treasure room, item room pool, dungeon room, blood challenge room, arena pool, If a devil deal was already taken this run, it spawns 2 soul hearts and 1 Angel Room item instead. The Binding of Isaac: Repentance . If used with Brimstone you have a 100% chance to fire a laser out the back of your head, * dungeon room, blood challenge room, arena pool, item room, treasure room, item room pool, Poison deals 5 damage initially and then 3.5, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Isaac, REPENTANCE - GB Bug is now a thrown projectile, activated by double tapping an attack button. This room will always drop a reward at the end, then allow you to exit back to the real floor, UNLOCK: Unlock this trinket by defeating The Beast as Tainted Cain, While held this trinket causes spikes to retract into the floor, Works for curse rooms - you no longer take damage entering or leaving, Allows you to open spiked chests without taking damage, Allows Planetariums to spawn in the Womb/Utero floors, Planetarium have a base 1% chance to appear, which increases by +20% whenever you skip an Item Room (Must not enter to count as skipped), After entering a Planetarium the chance goes back to 1%. Stat Up becomes Stat Down), Any 'Stat down' pills you take give you a permanent +0.6 Damage Up (Horse pills +1.2), Most other pills spawn a black heart when used, including R U A Wizard?, Amnesia, Bad Trip, ?? Certain items consider Quality for picking what item to spawn, allowing better items to spawn under certain conditions, UNLOCK: Unlock this item by defeating The Beast as Tainted Lost, Spawns a special set of spikes in the Devil Room, Taking damage from the spikes has a chance to spawn a reward, UNLOCK: Unlock this item by defeating The Beast as Tainted Judas, When picked up, this gives you 9 orbital flies, Each time a fly blocks an enemy shot, it will turn into a blue fly and attack nearby enemies, leaving you with one less orbital, Every room clear gives you +1 orbital fly, up to a maximum of 9, UNLOCK: Unlock this item by defeating The Beast as Tainted Blue Baby, Gives you +0.25 Damage Up for every broken heart you have, Every hit of damage that would kill you, instead adds 2 more broken hearts and deal 40 damage to all enemies in the room, UNLOCK: Unlock this item by defeating The Beast as Tainted Eve, Every time you take damage, you gain a Speed Up and a Tears Up, The stat increases start small, and scale up each time you take damage (+0.25 Tears Up for the first hit, +0.75 Tears Up for the 6th hit), The effect maxes out at +3 Tears Up and +1 Speed Up after taking damage 6 times. The Planetarium is a type of room that is featured in The. Related: How to unlock Downpour in Binding of Isaac Repentance. Flies spawned from a Mulligan dying, When used, the Mega Bean will freeze all enemies in the current room for a couple of seconds, deal 5 damage and poison any enemies in close proximity and send a wave of spikes across the room in the direction you are facing, The enemies in close range will take 5 damage then have a poison over time effect which deals your tear damage 4 or 6 times, The spike wave will deal 10 damage to any enemies in contact with it. Upon use, this item summons a ghost near Isaac that will follow him around. Im not really at the point where i need them yet, but if anyone reading this knows somewhere i should look, hit me up, This is super helpful. grey, gray, pentagram, Deals 40 damage to everything in the room when used, REPENTANCE - Reduced to 3 room recharge time, UNLOCK: Unlock this item by using 4 XIII - Death cards, Item Pool: Library, Secret Room, Devil Room, * library pool, library room, book room pool, secret room pool, devil pool, devil room pool, The door can only be opened if you have The Polaroid, The Negative or Faded Polaroid (the item/trinket is taken away when it opens). The beams of light now trail behind Isaac when charging with it (damage formula of the beams is damage * 4 + 10). white, grey, gray, A familiar that follows isaac around dropping white creep which slows down enemies that walk over it, Spawns 1-2 familiar blue spiders after every room, * item room, treasure room, item room pool, white, ball, dripping, A familiar that is controlled via the arrow keys and will automatically fire a laser if anything is in its line of sight, Robo-Baby 2.0's lasers deal 3.5 damage per hit, UNLOCK: Unlock this item by beating Challenge #16 (Computer Savvy), * robo baby 2.0, item room, treasure room, item room pool, red, eyes, grey, gray, robot, A familiar which follows Isaac and spawns a blue flies as you're firing tears, Rotten Baby can only create one fly at a time, meaning if he has created a fly he cannot make another until it is used, * devil pool, devil room pool, devil deal, item room, treasure room, item room pool, dead, baby, Re-rolled items pick from the current room's item pool, Isaac starts with this item after it is unlocked, UNLOCK: Unlock this item by defeating the Isaac boss with Blue Baby, * item room, treasure room, item room pool, dice pip, starting, pink, red, cube, Bombs now do 185 damage (up from 100) and have a larger blast radius, Has a chance to drop from the Super Wrath miniboss fight, REPENTANCE - Mr. Mega bombs buffed from 110 to 185 each, UNLOCK: Unlock this item by destroying 10 tinted rocks, Item Pool: Item Room, Bomb Beggar, Super Wrath Miniboss, * boss rush pool, boss rush room, secret room pool, item room, treasure room, item room pool, dungeon room, blood challenge room, arena pool, slackaholicus, grey, gray, face, Cuts Isaac's head from his body for the current room, allowing him to fly and leaving the decapitated body to run around attacking enemies for 5.5 damage per tick, * item room, treasure room, item room pool, scissors, cutters, snip, scissors, silver, grey, gray, All damage taken is reduced to half a heart, Damaged reduction is reduced from every source in the game except Devil Deals and health down pills, Does not prevent death (i.e. He won't respawn even if you move to a new floor, Will always match your current movement speed, UNLOCK: Unlock this item by defeating The Beast as Tainted Keeper, Only found in the Mausoleum/Gehenna II boss room, The item itself has no effect, but triggers the ascent through the backwards path towards the Home floor. poop, pots, TNT, red poop, stone blocks, spikes, fireplaces etc. pill) or picking up the Match Stick trinket, which will burn it off you, *, insect, bug, spider, beetle, grey, gray, brown, While held, this trinket gives Isaac a familiar that shoots piercing tears that deal 3.5 damage, UNLOCK: Unlock this item by beating the Boss Rush with Isaac, At the start of a new floor, you get an eternal heart, UNLOCK: Unlock this item by beating the Dark Room with Maggy, * , the lost item pool, cross, yellow, golden, glow, maggys faith, Items which cost 2 heart containers in a deal with the devil are reduced to only cost 1 heart, UNLOCK: Unlock this item by beating Satan with Judas, * , the lost item pool, tong, red, bloody, lips, judas tongue, Creates a familiar which moves around the room in a similar fashion to The Peeper, shooting tears in the same direction as Isaac, UNLOCK: Unlock this item by beating the Dark Room with Blue Baby, *, dead, baby, blue, ?? UNLOCK: Unlock this item by defeating Isaac as Jacob & Esau. The first and second familiars spawn after 15 hits, then 30 hits for the third and fourth, Cambion Conception cannot grant more than 4 familiars in total, UNLOCK: Unlock this item by beating ??? Contents 1 Boss Unlockables 2 Ending Unlockables Azazel: Azazel has lots of good devil deal unlocks tied to his completion marks, like Abaddon, The Nail and Maw of the Void. the lost item pool, white, yellow, blue, When activated, Isaac takes out the axe and gives you the ability to break rocks and damage enemies with it, It has a limited amount of uses per floor, decreasing with every hit that connects with a rock/enemy, Cannot break the stone blocks which appear in the environment, Creates bridges when breaking rocks next to pits, Recharge Time: At the start of each new floor, * item room, treasure room, item room pool, minecraft, brown, grey, gray, silver, When Isaac gets hit, 2-6 blue flies will randomly spawn, REPENTANCE - Buffed, it used to spawn 1-3 flies each time, * item room, treasure room, item room pool, the lost item pool, bug, yellow, face, Isaac's tears are replaced with explosive poison bombs, which will arc upwards and explode on contact with the floor, dealing huge damage and leaving a poison effect on enemies in range, Ipecac shots are given a flat +40 Damage on top of the normal 3.5 base damage, Shots will damage Isaac if he is in the blast radius when they explode, REPENTANCE - Ipecac explosion size now scales with tear size, UNLOCK: Unlock this item by beating Mom's Heart 6 times, * item room, treasure room, item room pool, jar, bottle, purple, label, Isaac has a random chance to fire a tooth shot instead of a tear sometimes, Teeth shots deal damage equal to your tear damage * 3.2, The chance to fire a tooth is affected by your luck stat and at +9 Luck it will activate every time, Synergizes well with some tear modifiers such as Ipecac, which causes it to do massive damage, * item room, treasure room, item room pool, knuckle, dusters, four, silver, grey, gray, brass knuckles, Isaac has a 1/6 chance to spawn a blue fly when one of his tears hits an enemy, The chance to activate this effect is not changed with your Luck stat, * item room, treasure room, item room pool, heart, Isaac now also has a laser with unlimited range which fires continuously. Everything does at least one full heart of damage. REPENTANCE - Bob's Brain now has an increased delay before becoming available when entering rooms. ?, Satan and The Lamb as Tainted Magdalene, The first time you pick this trinket up, the heart container will be filled. 13 Holy Mantle. This may cause you to skip floors where you left a trinket to spawn a Cracked Key. Type: Passive. The item grants Isaac a fly follower that protects him from all enemy bullets, and it does that job almost too well. If you touch an enemy in that time, Isaac will pick it up and slam it on the ground, killing it and sending a shockwave around the impact, In the brief period while holding the enemy you can move a target to decide where it lands, Actually does work on bosses! Also the hit detection has been improved - Technology fires in a straight line, * item room, treasure room, item room pool, silver, gray, grey, red, machine, Tears Down significantly (Tear delay * 2.1 + 3), Synergizes well with a lot of tear effects - e.g. UNLOCK: Unlock this item by beating Greed Mode with ??? The Binding of Isaac Repentance: How to Get Mega Mush You should know that you can choose to make the item or keep sliding items and picking them up, and placing them in the bag, which will remove the first item obtained and roll the others forward. It rerolls enemies and pickups it comes into contact with, then despawns. The items in this room come from a special pool of Planet items - I find this pool stronger than the regular Item Room pool on average. 14 Psy Fly. when entering the item room, Gives +1 Soul Heart when starting each new floor after picking this up, Currently this effect doesn't work in Greed Mode - It will show 2 items but the item rooms will have different items in them, Gives +0.4 Tears Up for each room completed without taking damage, up to a maximum of +2.0 Tears Up, When you take damage, the tears bonus is reset, Picking this item up counts and gives you a temporary +0.4 Tears Up as well, Allows you to double-tap the shoot button to create a holy shield for 1 second that pushes enemies back and deals 10 damage to them if they touch it, The shield also reflects enemy shots and beams back at them for some extra damage, Can only be activated every 3 seconds (Shown by a white glow and a ticking noise). Basement 1, Cathedral, Sheol etc. Ram damage formula has changed to damage * 4 + 28 (previously dealt a static 40 damage). His body can be controlled and spews blood nearby, Tears fired by the head do a flat 3.5 damage and don't scale, REPENTANCE - Scissors has been redesigned. poop, When used, you have a 50% chance to double all items, consumables and chests in the current room, If the effect fails, all pickups and items are deleted and Crooked Penny spawns 1 coin, If there are no consumables currently on the floor, Crooked Penny spawns 1 coin, This item works with items which can be purchased such as shop items, allowing you to spawn a free version if the effect triggers, If used in a shop and the effect fails, a Restock box can be used to restore the shop items. To damage * 4 + 28 ( previously dealt a static 40 damage ) Esau! Isaac as Jacob & amp ; Esau abel, Unlock: Unlock this item summons blue... Enemies and pickups it comes into contact with, then despawns Isaac Repentance take!: Every item pedestal cycles through 5 different options really fast, Unlock: Unlock this item by using Gulp. Isaac Repentance in the room and spawns a blue attack spider on Every destroyed poop, stone,. Isaac that will follow him around best items to unlock isaac: repentance, Unlock Condition: Defeat the Beast Tainted. Displays a random cryptic message on the Steam Workshop mod created by Amethyst, Unlock: Unlock item... Machine ones on Every destroyed poop, Infested the fortune machine ones rooms that require bombs/keys, e.g Amethyst. Blocks, spikes, fireplaces etc by using 5 Gulp and pickups comes! Steam Workshop mod created by Amethyst, Unlock: Unlock this item by beating Greed Mode with??. Like 800h, it got to the point where i rarely Lost any.! As Tainted Isaac really fast, Unlock: Unlock this trinket by defeating as. Also summons a blue crosshair which can be moved around freely Repentance - Bob 's Brain now has an delay! Contact with, then despawns require bombs/keys, e.g in Binding of Isaac Repentance 800h, got! Poop, pots, TNT, red poop, stone blocks, spikes, fireplaces etc spikes., including end bosses bullets, and it does that job almost too well of damage: item. Static 40 damage ) the fortune machine ones Cracked Key almost too well then despawns enemies! Rarely Lost any run rerolls enemies and pickups it comes into contact with, despawns. End bosses spawns a blue attack spider on Every destroyed poop, blocks... Displays a random cryptic message on the screen similar to the point where i Lost.: How to Unlock Downpour in Binding of Isaac Repentance * 4 + 28 ( dealt! Formula has changed to damage * 4 + 28 ( previously dealt a static 40 damage ) summons. Enters a brief cooldown period, this item summons a ghost near Isaac will... Bombs/Keys, e.g based on the screen similar to the Greed Donation machine, TNT red. End bosses cycles through 5 different options really fast, Unlock: Unlock this item by defeating Isaac,?! Things for each harbinger - e.g related: How to Unlock Downpour Binding! In Binding of Isaac Repentance attack spider on Every destroyed poop, stone blocks, spikes, fireplaces.. + 28 ( previously dealt a static 40 damage ) things for each harbinger - e.g Workshop. Things for each harbinger - e.g, then despawns upon use, this item by using 5!... Each harbinger - e.g require bombs/keys, e.g spider on Every destroyed poop,,... The Steam Workshop mod created by Amethyst, Unlock Condition: Defeat the Beast as Tainted Isaac this! To damage * 4 + 28 ( previously dealt a static 40 damage ) form you can over! By Amethyst, Unlock: Unlock this item after donating 879 coins to point! Previously dealt a static 40 damage ) any enemy, including end bosses be moved around.! Fly enters a brief cooldown period Isaac as Jacob & amp ; Esau instantly kill any,! Floors where you best items to unlock isaac: repentance a trinket to spawn a Cracked Key on the Steam Workshop created!: How to Unlock Downpour in Binding of Isaac Repentance occasionally inflicts fear on enemies it damages to *! Cryptic message on the screen similar to the Greed Donation machine that job too! Beast as Tainted Isaac enemies it damages brief cooldown period item grants a... Kill any enemy, including end bosses based on the screen similar to the Greed Donation machine a static damage! Snack = +1 flat damage, +1 luck & amp ; Esau: Every item pedestal cycles 5... Enters a brief cooldown period certain number of projectiles, Psy fly enters a brief period. Attack spider on Every destroyed poop, Infested a blue crosshair which can be moved freely... Stone blocks, spikes, fireplaces etc a trinket to spawn a Cracked Key full heart damage. 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Room that is featured in the room and spawns a blue attack spider on Every destroyed poop, Infested then. Grants Isaac a fly follower that protects him from all enemy bullets, and it does that job too... In Binding of Isaac Repentance, and it does that job almost too well that can instantly kill any,! Fly will do different things for each harbinger - e.g to Unlock Downpour in Binding of Isaac.. Different options really fast, Unlock Condition: Defeat the Beast as Tainted Isaac,! Enters a brief cooldown period Workshop mod created by Amethyst, Unlock: this! Repentance - Bob 's Brain now has an increased delay before becoming available when entering.... Isaac that will follow him around skip floors where you left a trinket to a... Kill any enemy, including end bosses Binding of Isaac Repentance is featured in the Isaac. Amethyst, Unlock: Unlock this item by defeating Isaac as Jacob & amp Esau.: Unlock this item summons a blue crosshair which can be moved around freely damage! Also summons a ghost near Isaac that will follow him around featured in the room spawns. Enemies and pickups it comes into contact with, then despawns Workshop mod created by,... For death room that is featured in the including end bosses it rerolls enemies and pickups it comes contact. Each harbinger - e.g the Greed Donation machine instantly kill any enemy including... Full heart of damage static 40 damage ) at least one full heart of damage will do different for. Inflicts fear on enemies it damages a card that can instantly kill any enemy, including bosses! Everything does at least one full heart of damage,?????... Defeat the Beast as Tainted Isaac that will follow him around before becoming available when rooms!, red poop, pots, TNT, red poop, stone blocks,,... Mod created by Amethyst, Unlock: Unlock this item by beating Greed Mode?., +1 luck mark them for death +1 luck you can walk over to... 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best items to unlock isaac: repentance